So far, it has been confirmed that many molecular biomarkers are related to the prognosis of glioma, including IDH, MGMT, TERT, 1p/19q, EGFR, TP53, BRAF etc. In this study, we aimed to explore the valuable of radiomics in conventional (T2W/T1W/T1W + C and diffusion (DWI/ADC MR combined with clinical features (clinical and MRI imaging characteristics to predict four kinds of glioma molecular biomarkers (IDH, MGMT, TERT, 1p/19q). Here, EGFR is linked to glioma.