A phase I, open-label, crossover study [9] compared the pharmacokinetic (PK) profile of BAY 81–8973 with antihemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM, ADVATE®) among men aged 18–65 years with severe hemophilia A and ≥ 150 exposure days to FVIII product and found that BAY 81–8973 exhibited a superior pharmacokinetic (PK) profile [9]. This evidence concerns the gene F8 and hemophilia A.