Huperzine A (Hup A) is a highly active alkaloid extracted and isolated from the herbal plant Huperzia serrata, and has been successfully used to treat myasthenia gravis and Alzheimer’s disease (AD) as a potent, reversible, and selective acetylcholinesterase (AChE) inhibitor [1–5]. This evidence concerns the gene ACHE and early-onset autosomal dominant Alzheimer disease.