The levels of phospho-Ser129 αS of the putamen in sarkosyl-insoluble fraction of LRRK2 G2385R were higher than those in the other LRRK2 variant or non-PD control group, whereas they were comparable to those in the sporadic PD control group (Fig. 2a, b). This evidence concerns the gene LRRK2 and Parkinson disease.