Similarly, the results also showed that Akt1 predominantly regulated retinal angiogenesis (Fig. 1a–d), tumor angiogenesis (Fig. 2c–f), EC proliferation (Fig. 3a, b), EC sprouting (Fig. 3c, d), Notch3 activation (Fig. 5d, f), and the inhibition of YAP (Fig. 6a–d). Here, YAP1 is linked to neoplasm.