In the course of EMT Ras oncoprotein is activated and cooperative signaling between Ras and TGFβ, during which Ras plays prominent role in the switch from tumor-suppressive to tumor-promoting signaling of TGFβ, is important for maintenance of complete EMT and for gaining the full invasive potential of cancerous cells8–11. Here, TGFB1 is linked to neoplasm.