NOTCH1 and acute lymphoblastic leukemia: Similar in-frame insertions of 11–36 amino acids stemming from internal tandem duplications in the 3’ end of intron 27 and/or the proximal region of exon 28 (NOTCH1 extracellular juxtamembrane region), called juxtamembrane expansion (JME) mutations, have been reported in T-ALL and ACC and are known to result in a strong constitutive production of NICD1 [71, 72].