NOTCH1 and adrenal cortex carcinoma: As whole-exome sequencing (WES) of these cell lines did not reveal any activating mutations in NOTCH genes (not shown), we established an organoid model (Supplementary Fig. 1A) using surgical resection material from a patient with an ACC tumor carrying two activating mutations in NOTCH1, as detected by the OncoPlus cancer mutation panel [68].