To exclude the possibility that another factor is affecting the lifetime GAF scores, we adjusted the analyses for mental diseases other than depression or anxiety disorders (e.g., substance use schizoaffective, psychotic, and bipolar disorders): the effect of CYP2C19 metabolizer status on lifetime GAF score remained significant (ß = 2.9, 95% CI: 0.84–5.0, p = 0.006, data not shown). The gene discussed is CYP2C19; the disease is bipolar disorder.