GSEA of these DEGs revealed that HNSCC samples with USP7 overexpression harbored genes significantly enriched with cancer-related gene signatures such as Myc-targets, EMT (Fig. 2C) and two previously reported Hippo-YAP/TAZ cancer signatures (Supplementary Fig. 6C) [9, 34]. This evidence concerns the gene WWTR1 and head and neck squamous cell carcinoma.