CCN2 and cancer: In addition, bioinformatics analyses of transcriptomic datasets from Cancer Cell Line Encyclopedia database revealed significantly positive associations between USP7 expression and CYR61/CCN1 (R = 0.4498, p < 0.0111), CTGF/CCN2 (R = 0.3141, p < 0.0426) in 31 HNSCC cell lines (Fig. 7E and Supplementary Fig. 13B).