After optimization and quality control of the methylome deconvolution model (for details, see “Methods”), we identified three main LMCs: LMC1 and LMC3 represented normal samples from Scgb1a1 and Sftpc lineages, respectively, whereas LMC2 represented a common lung cancer-specific signature (Fig. 4b). Here, SCGB1A1 is linked to lung carcinoma.