Additionally, three programmes depicted the tumour clusters (12, 13 and 14) described above: a stem-like tumour module correlated with cluster 14, and was characterized by stem cell markers such as Id2 and Sox9 together with AT2 identity genes like Sftpc, Lamp3 and Lcn2 (Fig. 6b, c and Supplementary Data 4); a regeneration-like tumour module that was mainly enriched in cluster 12 and similar to lung regeneration, this module showed high activity in HIF1 signalling, TGF-beta pathway, IL-17 signalling and metabolic pathways such as glycolysis (Supplementary Fig. 7c and Supplementary Data 4)18. The gene discussed is LCN2; the disease is neoplasm.