HIF1A and non-small cell lung carcinoma: Next, the investigation of the relationship between the autophagy-related genes (e.g., LC3 and p62) and hypoxia showed that hypoxia exposure increased LC3II/LC3I and HIF-1α levels, but decreased p62 levels in all three NSCLC cell lines, suggesting that hypoxia could induce autophagy (Fig. 1B, C).