CD8A and neoplasm: In addition, immunofluorescence staining of the macrophages (F4/80) and CD8+ T cells of the rechallenged tumors on day 16 after inoculation (Supplementary Fig. 14) also confirmed that the infiltrated populations of CD8+ T cells and macrophages in the cured mice were significantly higher than in the normal mice, suggesting that photo-irradiated aCD47/Ce6@PPG hydrogel successfully produced tumor-specific long-term memory immunity effect that was helpful to inhibit tumor recurrence and metastasis.