As pyruvate kinase M2 (PKM2) is the rate-limiting enzyme controlling the final step of glycolysis and serves as a major regulator of the Warburg effect in different cancer cells, the regulation of PKM2 by EGF, particularly in high EGFR–expressing cells, is thus of great importance (9, 10, 11, 12, 13). The gene discussed is PKM; the disease is cancer.