ENOSF1 and ectodermal dysplasia syndrome: Previously, a genetic linkage study on a large consanguineous Pakistani family, where affected members manifested clinical features of syndromic ectodermal dysplasia [ECTD (MIM: 616029)], has revealed a linkage candidate region on chromosome 18p11.32-p11.3, which includes the TYMS-ENOSF1 locus.43