Elegant recent work has shown that subpopulations both of Lgr5+ve and −ve tumor cells have elevated rDNA transcription and protein synthesis characteristic of functional stem cell activity (Morral et al., 2020) and that lineage conversion between cell types can be driven by the combination of key CRC driver genes and microenvironmental extracellular signaling (Han et al., 2020). Here, LGR5 is linked to neoplasm.