HAVCR2 and neoplasm: Both CD8+ and CD4+ Tcells also showed increased expression of the immune checkpoint molecules PD-1,LAG-3 and TIM-3 in KPAR tumours (Fig. 4D).Furthermore, KPAR tumours also contained a significant proportion of PD-1/LAG-3double-positive CD8+ T cells which were completely absent in KPB6tumours (Fig. 4E).