In the present study, we prepared a hepatocyte-specific FXR KO mouse using the Cre-flox system (AlbCre crossed with FXRflox/flox), followed by the infection of cercariae S. japonicum, we found that hepatocyte-specific FXR KO promoted weight loss and death of mice with schistosomiasis. This evidence concerns the gene NR1H4 and schistosomiasis.