In the present study, we prepared a hepatocyte-specific FXR KO mouse using the Cre-flox system (AlbCre crossed with FXRflox/flox), followed by the infection of cercariae S. japonicum, we found that hepatocyte-specific FXR KO promoted weight loss and death of mice with schistosomiasis. The gene discussed is NR1H4; the disease is infection.