Examples of recurrent cytogenetic entities implicated include t(8;21)(q22;q22.1); RUNX1/RUNX1T1, inv(16)(p13.1q22) or t(16;16)/ (p13.1q22) CBFB-MYH11, and acute promyelocytic leukemia (APL) t(15;17)(q22,q21) [23, 33]. Here, RUNX1 is linked to acute promyelocytic leukemia.