Other relevant mutations include the nucleophosmin-1 (NPM1) gene (40–50% normal karyotype AML) [42], and isocitrate dehydrogenase (IDH) 1 or 2 (IDH 1/2) enzymes, which are prevalent in about 20% of AML [23]. The gene discussed is IDH3A; the disease is acute myeloid leukemia.