Following confirmation of YAP1 depletion in these lines by Western blotting, we found that YAP1 depletion differentially increased esophageal cancer cell proliferation, migration and invasion abilities in KYSE-170, CE81T(1-0) and TE12 lines compared to to shLuc control cells (Figs. 1a-d and S2), suggesting a tumor-suppressive role of YAP1 in esophageal cancer cells. The gene discussed is YAP1; the disease is esophageal cancer.