Adrenocortical hormones, glucocorticoids (GC) and mineralocorticoids (MC), and adrenomedullary catecholamines exert essential effects on the components of BP: intravascular volume, peripheral retention of sodium and fluids, expansion of extracellular volume, hypokalemia, and suppression of plasma renin activity ( 4 ). This evidence concerns the gene REN and Hypokalemia.