Moreover, the activation of p-ERK1/2 is under the control of MAP3K2 via its regulatory roles for NF1, K-Ras and PP2A [22, 23] MAP3K2-ERK1/2 signaling pathway is thought to modulate the activation or expression of the STAT3, MMPs, survivin and cyclin D1, thus facilitating the invasion, metastasis and proliferation of cancer cells. Here, STAT3 is linked to cancer.