Tamoxifen-induced epidermal loss of cFLIP or pharmacological depletion of the IAPs, cIAP1, cIAP2, and XIAP, result in a complete loss of apoptosis inhibition, causing widespread keratinocyte death and severe, acute dermatological disease resembling toxic epidermal necrolysis (TEN) [100,101]. This evidence concerns the gene BIRC2 and toxic epidermal necrolysis.