TTR and amyloidosis: Whilst ATTRwt amyloidosis is a more homogeneous model of disease affecting predominantly elderly patients presenting with HFpEF, ATTRv amyloidosis has a polymorphic clinical presentation as some specific TTR mutation may predispose to a more severe cardiac involvement (i.e. V122I).5 Prognostic stratification in ATTR-CA remains challenging, as the diagnosis is made at different stages of the disease and the risk is dynamic over time due to progressive amyloid deposition in the heart.