Transthyretin (TTR) amyloidosis, also called ATTR amyloidosis, is an underappreciated, life-threatening disease characterized by progressive deposition of misfolded or cleaved TTR protein in organs.1,2 This condition results from age-related failure of homoeostatic mechanisms in wild-type ATTR (ATTRwt) amyloidosis (non-hereditary form) or destabilizing mutations in variant ATTR (ATTRv) amyloidosis (hereditary form).4 Disease occurs when aggregation of amyloid fibrils in the extracellular space disrupts the structure, integrity and function of the affected tissue. Here, TTR is linked to familial amyloid neuropathy.