The majority (> 70%) of patients in the United States are older men with ATTR-CA due to wild-type or Val122Ile TTR mutation compared to the rest of the world.5 Data from this registry provided information on natural history and outcomes in ATTR amyloidosis and demonstrated the presence of three main phenotypes at presentation: cardiomyopathy (ATTR-CA), polyneuropathy (ATTR-PN) and mixed. This evidence concerns the gene TTR and polyneuropathy.