Plasmin was reported to selectively cleave TTR between residues 48 and 49 under physiological conditions in vitro leading to release of truncated and full-length oligomers that rapidly aggregate and form fibrils.67 Furthermore, amyloidogenic cleavage has been recently proposed as alternate mechanism to tetramer dissociation in ATTR amyloidosis. The gene discussed is TTR; the disease is amyloidosis.