Several previous studies have reported that ACE2 is indeed found on the surface of vascular endothelial cells, and that SARS-CoV-2 dysregulates the renin-angiotensin-aldosterone system (RAAS) by inducing changes in endothelial ACE2 expression which contributes to endotheliopathy in COVID-19[19,22-24]. Here, ACE2 is linked to COVID-19.