PTK2 and cancer: Although ECM remodelling was previously thought to be predominantly mediated by cancer-associated fibroblasts (CAFs), recent studies suggest that both CAFs and cancer cells mediate tissue tension through the activation of mechano-signalling pathways such as; the integrin-Src-FAK signalling axis, JAK/STAT signalling and Rho kinases, which are all known to regulate cancer progression, metastasis and chemoresistance [9,17–22].