SMPD1 and Fabry disease: TRPML1 signaling or TRPML1‐mediated Ca2+ release is similarly impaired in other LSDs such as Niemann–Pick type C1 (NPC1) (Shen et al, 2012), Niemann–Pick type A (NPA; also called infantile neurovisceral form of acid sphingomyelinase (SMPD1) deficiency) (Zhong et al, 2016), and Fabry disease (Zhong et al, 2016).