MCOLN1 and Parkinson disease: Indeed, stimulation of lysosomal exocytosis via TRPML1 has recently been shown to clear α‐synuclein accumulation in Parkinson's disease dopaminergic neurons (Tsunemi et al, 2019), while another study demonstrated that activation of TRPML1 cleared amyloid‐beta (Aβ), which accumulates by unknown mechanisms in the lysosomal and autophagic compartments of neurons in the HIV‐infected brain (Bae et al, 2014).