HSP90B2P and Alzheimer disease: Further, prior in vivo work in AD transgenic mice has suggested that HSP mechanisms might be impaired, since chronic hypo- or hyper-activity via either long term sleep deprivation or induction, or unilateral whisker removal, conditions in which HSP should be engaged, negatively impacted AD transgenic compared to wild-type (WT) mice (Kang et al., 2009; Tampellini et al., 2010).