HSP90B2P and Alzheimer disease: Defective HSP could help explain why AD transgenic mice are more susceptible to pharmacologically-induced and spontaneous seizures (Minkeviciene et al., 2009; Reyes-Marin and Nuñez, 2017) and could provide a framework for explaining the increased sensitivity to seizures in AD patients (Pandis and Scarmeas, 2012).