ESR2 and Alzheimer disease: In 2022, we obtained NIH funds to carry out a Phase IIb randomized, placebo-controlled clinical trial testing the efficacy of PhytoSERM, a selective estrogen receptor beta (ERβ) modulator comprised of three phytoestrogens: genistein, daidzein, and S-equol (Zhao et al., 2009), for AD prevention in midlife women.