Additionally, peri-menopausal and post-menopausal women positive for ApoE4 genotype exhibited the highest Aβ burden (Mosconi et al., 2017, 2021), supporting the notion that ApoE4 genotype exacerbates AD-related brain changes in women with onset in the perimenopause (Riedel et al., 2016). This evidence concerns the gene APOE and Alzheimer disease.