APOE and Alzheimer disease: Recent multi-modality neuroimaging investigations targeting women at different menopausal stages (pre-menopausal, peri-menopausal, and post-menopausal), all carrying risk factors for AD, such as ApoE4 genotype and a family history of late-onset AD, demonstrate emergence of AD endophenotypes in women of peri-menopausal age (Mosconi et al., 2017, 2018a,b, 2021; Rahman et al., 2020).