CD4 and neoplasm: Analysis of the TISIDB database showed that PBRM1 abnormalities (including gene expression, mutation, CNA and gene methylation) were significantly associated with a variety of TILs, including activated CD4 (Figure 5A) and CD8 T cells (Figure 5B), activated dendritic cells, monocytes, dendritic cells and natural killer cells (NK cells) (Table 2), indicating that they can significantly contribute to tumor immune activity.