Single-cell RNA-seq analysis of sorted CD45+ immune cells showed that gene expression signatures were associated with tumor immunity (IFN-γ response, IFN-α response, and tumor necrosis factor-α signaling through NF-κB) in myeloid cells (dendritic cells and M1-like macrophages) and lymphocytes (T cells and natural killer cells) in PBRM1-deficient individuals (15). This evidence concerns the gene TNF and neoplasm.