Studies have found that SWI/SNF subunit ARID1A deficiency attenuates mismatch repair (MMR) capacity, impairs mismatch repair in a variety of cancers, leads to genomic alterations in microsatellite instability (22, 23), increases TMB, increases neoantigen presentation, increases TILs, and makes tumors susceptible to immune checkpoint blockade. Here, ARID1A is linked to cancer.