PLAT and brain ischemia: Currently, the thrombus-dissolving agents, such as tissue plasminogen activator (tPA), are available for the treatment of ischemic stroke; however, a narrow time window for the use of these agents and cerebral ischemia/reperfusion injury often cause serious pathological reactions, which produce unsatisfactory results of these conventional treatment approached for ischemic stroke (Mihalko et al., 2022).