PITX2 and atrial fibrillation: After the overall AADs, PITX2+/− deficient AF was more easily defragmented (49.3 vs. 34.7%, p = 0.014) and had a greater significant reduction in the mean DF (p < 0.001) and mean Smax (p = 0.001) as compared to the wild type (Table 2; Figure 3).