In this study, we evaluated the differential expression of TMUB1 between specimens from patients with CRC and normal tissues, performed correlation analysis between the TMUB1 expression and clinicopathological factors to assess the prognostic role of TMUB1, and identified relevant pathways and immune cell types associated with the high level of expression of TMUB1 observed in tumor samples from patients with colorectal cancer. The gene discussed is TMUB1; the disease is colorectal carcinoma.