In this study, we found that when circ_0000512 was overexpressed, the protein levels of E-cadherin were significantly decreased (P < 0.05) and N-cadherin and Snail were significantly increased in cells, which subsequently promoted occurrence of EMT in GBM cells; however, silencing circ_0000512 inhibited the process of EMT. This evidence concerns the gene SNAI1 and glioblastoma.