− Waist circumference ≥90/80 cm in men and women− SBP ≥ 130 mmHg and DBP ≥ 85 mmHg; antihypertensive therapy− Plasma triglycerides ≥150 mg/dl (≥1.70 nmol/L); lipid-lowering drug therapy− Plasma HDL-cholesterol <40 mg/dl (<1.0 mmol/L) and <50 mg/dl (<1.3 mmol/L) respectively for men and women; specific drug treatment− Diagnosis of prediabetes or HbA1c 5.7% to 6.4%− Homeostasis model assessment (HOMA)—insulin resistance score ≥ 2.5− Plasma high-sensitivity C-reactive protein (h-CRP) level > 2 mg/L. This evidence concerns the gene CRP and Insulin resistance.