IDH2 and central nervous system cancer: With progress in research on the molecular mechanisms of glioma, glioma subtypes have gradually shifted from histological classifications, such as diffuse astrocytomas and oligodendroglial cell tumors, to molecular classifications, such as isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) point mutations and 1p/19q co-deletions (2).