With progress in research on the molecular mechanisms of glioma, glioma subtypes have gradually shifted from histological classifications, such as diffuse astrocytomas and oligodendroglial cell tumors, to molecular classifications, such as isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) point mutations and 1p/19q co-deletions (2). The gene discussed is IDH2; the disease is glioma.