Thus, overexpressed TMEM100 suppressed the migration as well as angiogenesis induction capacity of CRC cells, but these effects were reversed by blocking the ubiquitin/proteasome degradation pathway process using MG132, which hinted that TMEM100 inhibited the migration and the angiogenesis induction capacities of CRC cells by impacting HIF-1α degradation via the ubiquitination/proteasome pathway (Figure 6E). The gene discussed is HIF1A; the disease is colorectal carcinoma.