PTGS2 and Familial adenomatous polyposis: identified that overrepresentation of COX2 was associated with a high risk for CRC development in patients with familial adenomatous polyposis (FAP) who had the rs689466 polymorphism GG genotype compared with AA genotype carriers (OR = 2.81; 95% CI = 1.00–7.91, P= 0.042) (34).