PTGS2 and colorectal carcinoma: COX enzymes (COX1, COX2) are important factors in the biosynthetic pathway of PGs from AA. ALOX enzymes (ALOX5, ALOX12, and ALOX15) convert PUFA to fatty acid hydroperoxides, which results in the production of LTs. Recent studies reported an association between the CRC risk with the amount of fatty acids intake and COX and ALOX polymorphisms (Figure 4).