PTGS2 and polyp of large intestine: In this line, the Minnesota-based case-control study discovered that COX2 gene expression or COX2 enzyme activity is suppressed and the risk of colorectal polyps is reduced by NSAIDs in individuals with the GG genotype of COX2 rs20417 (OR: 0.66; 95% CI: 0.48–0.92) (29).