investigated the association between the COX2 position 765 G<C, 8473 T>C, and 9850 A>G and CRC risk and reported that among the studied polymorphisms, COX2 8473T>C may reduce the CRC risk in people who consume NSAIDs (OR: 1.57, 95% CI: 1.04–2.38) (32). This evidence concerns the gene PTGS2 and colorectal carcinoma.