There was a positive association between low intake of DHA and increased risk of colon cancer with COX1 rs10306110. There was a positive association between higher inflammatory score and increased risk of colon cancer with wild type ALOX15 rs11568131. There was an inverse association between low total fat intake and rectal cancer risk with COX1 rs10306122. There was an inverse association between low inflammatory score and rectal cancer risk with COX2 rs4648276. Here, PTGS1 is linked to colonic neoplasm.