About 10% of PNEN patients are hereditary, mainly related to autosomal dominant inheritance, such as multiple endocrine neoplasms type I (MEN1), neurofibromatosis type I (NF-1), tuberous sclerosis (TSC), etc. MEN1 is the most common type, while TSC type only accounts for about 1%. The gene discussed is NF1; the disease is tuberous sclerosis.