Genera Desulfovibrio, Blautia, and unclassified f Lachnospiraceae, which were enriched in the offspring of HF dams, were positively correlated with body weight, FBG, leptin, insulin, T-CHO, and LDL-C, among which Desulfovibrio and Blautia were all negatively correlated with adiponectin. The gene discussed is ADIPOQ; the disease is hydrops fetalis.