TMPRSS2 and acute kidney injury: Finally, since the underlying cause of AKI is invasion of kidney cells by SARS-CoV-2, research should focus on drugs capable of interfering with the binding of SARS-CoV-2 with cell receptors (ACE2 and TMPRSS2), with cell endocytosis of the virus and altering the pH of lysosomes where the virus crosses once inside the cell.