ELANE, for example, is negatively correlated with AIM2, CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, CASP9, GSDMB, GSDMC, GZMA, IL1B, IL6, NLRP1, NLRP2, NLRP3, NOD1, NOD2, PJVK, PLCG1, PRKACA, SCAF11, TIRAP, and TNF. Therefore, the expression of these pyroptosis-related genes in COVID-19 patients presents complex patterns (Figure 1B). The gene discussed is AIM2; the disease is COVID-19.