PIMREG was associated with several immune-related biological processes in GBM, including leukocyte migration, cytokine secretion, interleukin 6 production, T cell activation, macrophage activation, adaptive immune response, cell adhesion regulation, NK cell activation, positive regulation of cell adhesion, activation of T cells, neuroinflammatory responses, negative regulation of cell activation, neutrophil-mediated immunity, production of interleukin 1, and immune effector process regulation. Here, IL6 is linked to glioblastoma.