TNF and glioblastoma: In GBM, KEGG pathway enrichment analysis showed that PIMREG was associated with the cell cycle, P53 cell pathway, and oocyte meiosis and negatively associated with the NF-κB pathway, cytokine–cytokine receptor interaction, Toll-like receptor signaling pathway, Th17-cell differentiation, TNF pathway and other pathways (Figure 9F).