Except for PD-1, CTLA4, and LAG3, the expression of other immunosuppression-related genes, such as LGALS1 and IGFBP2, is higher in glioma patients, and blocking the expression of immunosuppression-related genes can reshape the immunosuppressive microenvironment (34, 35). This evidence concerns the gene IGFBP2 and central nervous system cancer.