CACNA1G and Cerebellar atrophy: An extreme example of GOF is represented by mutations in CACNA1G associated with early-onset cerebellar atrophy, in which A961T and M1531V mutations in Cav3.1’s from DII-S6 and DIII-S6 (respectively) result in drastically slower current inactivation kinetics and a –10 mV shift in the voltage dependence of SSI (Chemin et al., 2018).