CACNA1I and epilepsy: Abnormal electrical oscillations of the cortico-thalamo-cortical network have been shown to underlay childhood absence epilepsy (CAE) and other idiopathic forms of epilepsy (Gobbo et al., 2021), while dysfunction to the thalamocortical network caused by altered Cav3.3 activation that increases tonic firing has been linked to absence epilepsy (Lee et al., 2014).