Interestingly, CACNA1I knockout mice lacking TRN rebound bursting also evidence disrupted sleep spindles (Astori et al., 2011), while sleep disorders and sleep deprivation constitute known migraine triggers (Bigal and Lipton, 2008; Odegard et al., 2010; Wober and Wober-Bingol, 2010). Here, TNPO1 is linked to migraine disorder.