Notably, four of the probands that carry rare CACNA1I variants were also found to carry rare variants in other genes potentially associated with migraine: DGR211 (p.R111G, CACNA1I) had a variant annotated to be benign variant in PRRT2 (p.P216L) and DGR32 (p.D302G, CACNA1I) carries a likely benign deletion variant in PNKD (p.M381_H382del). The gene discussed is CACNA1I; the disease is migraine disorder.