Rather, it could arise from hyperexcitability of the temporal lobe involved in passive IA because KCNQ2+/− mice show a heightened seizure susceptibility against kainic acid (Kim et al., 2019), which induces status epilepticus arising from the temporal lobe (Levesque and Avoli, 2013). The gene discussed is KCNQ2; the disease is status epilepticus.