In addition to seizures, patients with EE develop neurodevelopmental delay and intellectual disability (Zhang et al., 2020) and de novo dominant mutations in KCNQ2 and KCNQ3 genes have recently been associated with neurodevelopmental delay without seizures (Coe et al., 2019), suggesting the possible role of Kv7 channels in learning and memory (Baculis et al., 2020). This evidence concerns the gene KCNQ2 and Neurodevelopmental delay.