KCNQ2 and Cognitive impairment: Minimal disruption of memory in KCNQ2+/− mice (Figures 1–3), which lacks spontaneous seizures (Watanabe et al., 2000; Kim et al., 2019), is in sharp contrast to cognitive deficits induced by genetic ablation of IM in mice, which display spontaneous seizures (Peters et al., 2005; Milh et al., 2020; Kim et al., 2021).