Underscoring the critical roles of Kv7 channels in inhibiting neuronal excitability (Greene and Hoshi, 2017; Baculis et al., 2020), the agonist retigabine reduces seizures in animal models and humans (Miceli et al., 2008), whereas dominant mutations in either Potassium Voltage-Gated Channel Subfamily Q Member 2 (KCNQ2) or Potassium Voltage-Gated Channel Subfamily Q Member 3 (KCNQ3) genes cause neonatal epilepsy that includes benign familial neonatal epilepsy (BFNE) and epileptic encephalopathy (EE) (www.rikee.org, www.ncbi.nlm.nih.gov/clinvar/). The gene discussed is KCNQ2; the disease is ethylmalonic encephalopathy.