In a previous study, we reported that imDCs transfected with FOXP3: 1) still manifested the imDCs phenotypes; 2) inhibited the proliferation of CD4+T cells isolated from the animal model of MS -- Experimental autoimmune encephalomyelitis (EAE) mice; 3) inhibited the production of Th1 and Th17 cell-associated cytokines and enhanced the production of Th2 and Treg cell-associated cytokines, thus reversing the Th/Treg imbalance in the in vitro mixed lymphocyte-DCs culture assay 17. The gene discussed is FOXP3; the disease is experimental autoimmune encephalomyelitis.