It is well-established that Th1 and Th17 cells not only represented a major initiator but was also a participant in the pathogenesis and progression of MS as well as its animal model—EAE: 1) In MS, raised proportion of Th1 and Th17 cells in the peripheral blood and increased concentrations of Th1- and Th17-related cytokines such us IFN-γ, TNF-α, IL-6, IL-17, IL-21, IL-22, and IL-23 in the serum had been mentioned in numerous previous studies 2, 9, 29. Here, IL21 is linked to myeloid sarcoma.