The frequencies of MDSCs and CD68+CD163+M2-like macrophages of NSCLC patients in the post-RT group returned to the level of NSCLC patients in the pre-RT group, which could illustrate that the percentages of MDSCs and CD68+CD163+M2 macrophages were transiently increased in NSCLC patients during radiotherapy due to the inflammation reaction caused by ionizing radiation, and CD68+CD163+M2 macrophages could be different from M2 or alternatively activated macrophages. The gene discussed is CD68; the disease is non-small cell lung carcinoma.