Intranasal delivery of neurotrophins, such as NGF, to the brain via the olfactory bulb and the trigeminal nerve pathways is well tolerated (Alcalá-Barraza et al., 2010) and leads to substantial concentrations of neurotrophic products (Aloe et al., 2012), in particular in the frontal and parietal cortices (Lioutas et al., 2015), which are most often affected by stroke. Here, BDNF is linked to Stroke.