More studies showed that HSP22 protects mitochondrial function, inhibits mitochondrial apoptosis pathway, resists oxidative stress, and promotes myocardial cell survival and energy metabolism in animal myocardial infarction models, thereby improving myocardial ischemia and heart failure symptoms after myocardial infarction.359, 360. This evidence concerns the gene HSPB8 and myocardial infarction.