HSP90 plays a crucial role in the conformational maturation, protein stability, and function of oncogenic signaling, such as mutated p53, AKT, HER2/ERBB2, BCR‐ABL, and RAF1, as well as many other members that are important in cell cycle progression and immune responses, and it has been recognized as a potential therapeutic target for a number of diseases correlated with aberrant protein signaling, especially in cancers.257, 258. The gene discussed is AKT1; the disease is cancer.