HSP27 reduced the extent of myocardial infarction inducing by closure of the left anterior descending coronary artery, therefore enhanced cardiac function in the Langendorff perfusion model of isolated mouse hearts, implying that HSP27 may be involved in cardiomyocyte protection during persistent myocardial ischemia.293, 294, 295, 296. The gene discussed is HSPB2; the disease is myocardial ischemia.