For example, HSP90, HSP70, HSP60, HSP27, and HSF1 have been investigated as potential biomarkers for patient outcomes in multiple cancers, including lung cancer, breast cancer, CRC, pancreatic carcinoma, hepatocellular carcinoma, ovarian cancer, PC, and leukemia.112, 266, 332, 335, 385. The gene discussed is HSPB3; the disease is pachyonychia congenita.