IER5L and cancer: Prognostic Lasso analysis was used to construct and screen prognostic models, revealing that the expression of CTAG1A, CSTL1, FJX1, IER5L, and KLHL35 was higher in metastatic cancers than in primary cancers, indicating that the significantly higher expression of these five genes may drive cancer cell metastasis (Figures 3A,B).