ESR2 and major depressive disorder: Ultimately, data from 10 studies were included in our meta-analysis of the roles of ERα and ERβ in susceptibility to depression in women (Tsai et al., 2003; Kim et al., 2010; Ryan et al., 2012; Pinsonneault et al., 2013; Zhang et al., 2014; Kang et al., 2015; Różycka et al., 2016; He et al., 2017; Zhang et al., 2017; Tan et al., 2018).